A year has passed since the events of "The Mantis Variant - Book One" and the clash between the underground and the tower. A group of Biological Shifts has started slaughtering Messiahs in Teshon City. To find the culprits, the Principal Messiah establishes a task force to investigate the murders. Meanwhile, the mystic and his husband with their group of friends convince Dozi to take a trip. They help a child while away, but when they return to Teshon City, the streets become a battleground. Who will survive this new confrontation and what will be left of them?