Major advances in computing are occurring at an ever-increasing pace. This is especially so in the area of high performance computing (HPC), where today's supercomputer is tomorrow's workstation. High Performance Computing Systems and Applications is a record of HPCS'98, the 12th annual Symposium on High Performance Computing Systems and Applications. The quality of the conference was significantly enhanced by the high proportion of keynote and invited speakers. This book presents the latest research in HPC architecture, networking, applications and tools. Of special note are the sections on computational biology and physics. High Performance Computing Systems and Applications is suitable as a secondary text for a graduate-level course on computer architecture and networking, and as a reference for researchers and practitioners in industry.