Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.
Major scientific advances in molecular and clinical immunology have produced tremendous growth in our understanding of how cancer is recognized by the immune system, as well as in our ability to control and modulate that recognition. In Immunotherapy of Cancer, expert bench and clinical scientists join forces to concurrently review both the state of the art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T-cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunological monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.
Comprehensive and cutting-edge, Immunotherapy of Cancer offers immunologists an exhaustive and authoritative survey of cancer immunotherapy, as well as providing a springboard for applying the most important findings in tumor immunology to any basic laboratory program or clinical oncology practice.
From the reviews:
"Immunotherapy of Cancer provides in 28 chapters a comprehensive overview of experimental and clinical achievements in tumor immunology. Each chapter is designed to give the reader the scientific basis behind the discussed therapy and outline basic theory, as well as practical treatment applications. ? The book belongs to the successful series of publications Cancer Drug Discovery and Development from Humana Press. It will be of interest to clinicians and to laboratory cancer researchers ? ." (Cestmir Altaner, Neoplasma, Vol. 54 (2), March, 2007)
